Chicken Bubble Biscuit Bake Casserole is one of those magical dishes that seems to bring everyone together around the dinner table. With its comforting flavors and heartwarming aroma, it’s perfect for a cozy family meal or a potluck gathering. Plus, it’s incredibly easy to whip up, making it an ideal weeknight dinner when you need a satisfying and delicious meal without spending hours in the kitchen.
Why you’ll love this dish
This Chicken Bubble Biscuit Bake Casserole stands out for many reasons. First off, it’s a budget-friendly meal that makes use of common pantry ingredients and leftover chicken, so you can enjoy it without breaking the bank. It’s packed with protein and veggies, making it a wholesome option for all ages. Kids love its comforting taste, while adults appreciate its simplicity and heartiness.
“This casserole never fails to impress! It’s the ultimate comfort food that my whole family devours. Even my picky eaters can’t resist it!”
Whether you’re looking for a quick weeknight fix, a dish to bring along to a family gathering, or something to serve on a chilly day, this recipe checks all the boxes. The combination of fluffy biscuits, creamy filling, and melty cheese makes it a family favorite, ensuring that you’ll want to keep this recipe in rotation.
The cooking process explained
Making this Chicken Bubble Biscuit Bake Casserole is an absolute breeze. With just a few simple steps, you’ll transform basic ingredients into a hearty casserole that will warm your home and your heart. Here’s a quick overview of how it comes together:
- Preheat your oven and prepare your baking dish.
- Mix up the creamy chicken filling.
- Fold in the biscuit pieces.
- Assemble it all in the dish and top with cheese.
- Bake until golden and bubbly.
Now that you know the process, let’s gather those ingredients!
What you’ll need
To create this delightful casserole, you’ll need:
- 2 cups cooked chicken (shredded or diced; rotisserie works great)
- 1 (10.5 oz) can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
- 1 (16 oz) can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Feel free to substitute cream of chicken with cream of mushroom for a different flavor profile. Additionally, if you’re looking to cut calories, you can use Greek yogurt instead of sour cream.
Step-by-step instructions
Follow these straightforward directions to create your Chicken Bubble Biscuit Bake Casserole:
- Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
- In a large bowl, mix together the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until everything is well combined and smooth.
- Gently fold in the quartered biscuit pieces until they are fully coated in the creamy mixture.
- Pour the mixture into the prepared baking dish and spread it evenly. Sprinkle the shredded cheese generously over the top.
- Cover the dish with foil and bake for 20 minutes. Then, remove the foil and continue baking for an additional 10 to 15 minutes, or until the biscuits are puffed, golden, and fully cooked.
- If desired, brush the top with melted butter before serving. Allow the casserole to cool slightly for about 5 minutes before digging in.

Best ways to enjoy it
To serve your Chicken Bubble Biscuit Bake Casserole, consider pairing it with a fresh green salad or steamed vegetables for a balanced meal. You might also enjoy it alongside a side of crusty bread, which is perfect for soaking up the delicious sauce. This dish looks inviting in the baking dish itself, but you can also serve individual portions for a cozy presentation.
Storage and reheating tips
Leftover Chicken Bubble Biscuit Bake can be stored in an airtight container in the refrigerator for up to 3 days. If you want to keep it longer, consider freezing the casserole before baking. Just wrap it tightly in foil and store it in the freezer for up to 2 months. When you’re ready to bake from frozen, simply thaw it in the refrigerator overnight before following the baking instructions.
For reheating, warm your individual servings in the microwave or re-bake the casserole at 350°F until heated through, about 25–30 minutes.
Helpful cooking tips
To elevate your Chicken Bubble Biscuit Bake Casserole, consider the following tips:
- For an extra layer of flavor, sauté some onions or mushrooms to add to the filling.
- Try mixing in different cheeses for a unique taste, like pepper jack for a bit of heat or a blend of cheeses for depth.
- If you want more vegetables, feel free to add spinach or broccoli to the mix!
Creative twists
This recipe is incredibly versatile and can be customized to suit your taste preferences. Here are a few ideas:
- Swap out the mixed vegetables for seasonal veggies to reflect what’s in your garden or at your farmer’s market.
- Use a different protein, such as turkey or even cooked sausage, to give the dish a new flavor.
- Replace the biscuit dough with a layer of puff pastry for a different texture and added elegance.
Common questions
How long does it take to prepare Chicken Bubble Biscuit Bake Casserole?
The prep time is about 15 minutes, and baking takes around 30–35 minutes, making this an excellent choice for a weeknight dinner.
Can I make this casserole ahead of time?
Yes! You can assemble the casserole in advance, cover it, and store it in the refrigerator for up to a day before baking. This makes it convenient for busy evenings.
Is it safe to freeze leftovers?
Absolutely! Just ensure that the casserole is stored in an airtight container. When reheating, make sure it’s heated through to the center to ensure food safety.
With this comforting and delicious Chicken Bubble Biscuit Bake Casserole, you’re not just preparing a meal—you’re crafting a cherished family experience that will keep everyone coming back for seconds. Happy cooking!
Chicken Bubble Biscuit Bake Casserole
Ingredients
Method
- Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
- In a large bowl, mix together the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until everything is well combined and smooth.
- Gently fold in the quartered biscuit pieces until they are fully coated in the creamy mixture.
- Pour the mixture into the prepared baking dish and spread it evenly. Sprinkle the shredded cheese generously over the top.
- Cover the dish with foil and bake for 20 minutes. Then, remove the foil and continue baking for an additional 10 to 15 minutes, or until the biscuits are puffed, golden, and fully cooked.
- If desired, brush the top with melted butter before serving. Allow the casserole to cool slightly for about 5 minutes before digging in.